New Publication – Support for the slip hypothesis from whisker-related tactile perception of rats in a noisy environment

Rodents use active whisker movements to explore their environment. The “slip hypothesis” of whisker-related tactile perception entails that short-lived kinematic events (abrupt whisker movements, called “slips”, due to bioelastic whisker properties that occur during active touch of textures) carry the decisive texture information. Supporting this hypothesis, previous studies have shown that slip amplitude and frequency occur in a texture-dependent way. Further, experiments employing passive pulsatile whisker deflections revealed that perceptual performance based on pulse kinematics (i.e., signatures that resemble slips) is far superior to the one based on time-integrated variables like frequency and intensity. So far, pulsatile stimuli were employed in a noise free environment. However, the realistic scenario involves background noise (e.g., evoked by rubbing across the texture). Therefore, if slips are used for tactile perception, the tactile neuronal system would need to differentiate slip-evoked spikes from those evoked by noise. To test the animals under these more realistic conditions, we presented passive whisker-deflections to head-fixed trained rats, consisting of “slip-like” events (waveforms mimicking slips occurring with touch of real textures) embedded into background noise. Varying the (i) shapes (ramp or pulse); (ii) kinematics (amplitude, velocity, etc.); and (iii) the probabilities of occurrence of slip-like events, we observed that rats could readily detect slip-like events of different shapes against noisy background. Psychophysical curves revealed that the difference of slip event and noise amplitude determined perception, while increased probability of occurrence (frequency) had barely any effect. These results strongly support the notion that encoding of kinematics dominantly determines whisker-related tactile perception while the computation of frequency or intensity plays a minor role.

Read more…

C. Waiblinger, D. Brugger, C. J. Whitmire, G. B. Stanley, C. Schwarz, Support for the slip hypothesis from whisker-related tactile Perception of rats in a noisy environment, Frontiers in Integrative Neuroscience 9:53, 2015. PDF

New Publication – Electrical and Optical Activation of Mesoscale Neural Circuits with Implications for Coding

imageArtificial activation of neural circuitry through electrical microstimulation and optogenetic techniques is important for both scientific discovery and clinical translation. However, neural activity generated by these artificial means differs dramatically from normal circuit function, both locally and in the propagation to downstream brain structures.The precise nature of these differences and the implications for information processing remain unknown. In this work, we directly compare the effects of artificial and sensory stimulation on information propagation in the thalamocortical circuit.

D. C. Millard, C. J. Whitmire, C. A. Gollnick, C. J. Rozell, G. B. Stanley, Electrical and optical activation of mesoscale neural circuits with implications for coding, J Neurosci 35(47):15702-15715, 2015 PDF<

Article abstract: Artificial activation of neural circuitry through electrical microstimulation and optogenetic techniques is important for both scientific discovery of circuit function and for engineered approaches to alleviate various disorders of the nervous system. However, evidence suggests that neural activity generated by artificial stimuli differs dramatically from normal circuit function, in terms of both the local neuronal population activity at the site of activation and the propagation to downstream brain structures. The precise nature of these differences and the implications for information processing remain unknown. Here, we used voltage-sensitive dye imaging of primary somatosensory cortex in the anesthetized rat in response to deflections of the facial vibrissae and electrical or optogenetic stimulation of thalamic neurons that project directly to the somatosensory cortex. Although the different inputs produced responses that were similar in terms of the average cortical activation, the variability of the cortical response was strikingly different for artificial versus sensory inputs. Furthermore, electrical microstimulation resulted in highly unnatural spatial activation of cortex, whereas optical input resulted in spatial cortical activation that was similar to that induced by sensory inputs. A thalamocortical network model suggested that observed differences could be explained by differences in the way in which artificial and natural inputs modulate the magnitude and synchrony of population activity. Finally, the variability structure in the response for each case strongly influenced the optimal inputs for driving the pathway from the perspective of an ideal observer of cortical activation when considered in the context of information transmission.

Stanley lab receives NIH Brain Initiative award

The Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative is part of a new Presidential focus aimed at revolutionizing our understanding of the human brain. By accelerating the development and application of innovative technologies, researchers will be able to produce a revolutionary new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space. Long desired by researchers seeking new ways to treat, cure, and even prevent brain disorders, this picture will fill major gaps in our current knowledge and provide unprecedented opportunities for exploring exactly how the brain enables the human body to record, process, utilize, store, and retrieve vast quantities of information, all at the speed of thought.

The Stanley Lab in Conjunction with Dieter Jaeger’s Lab at Emory received a joint award to explore the sensory-motor pathway and how it can be affected by modulating inputs.

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Aurelie Pala joins the Stanley Lab


Auralie Pala will be joining the Stanley lab as a post doctoral researcher beginning in December. She comes to us from Carl Peterson’s lab at the Ecole Polytechnige Federale de Lausanne (EPFL) in Lausanne Switzerland. Her PhD work was in 2-photon guided patching exploring cell type specific cortical connectivity.

SfN 2015 Poster Preview

We will have multiple posters at the Society for Neuroscience meeting in Chicago next week. Please plan to stop by and check them out!

Saturday, Oct 17, 2015, 1:00 PM – 5:00 PM
  • 65.01/M37: Controlling transmission of sensory information by optical manipulation of the thalamo-cortical pathway in the anesthetized mouse. *P. BORDEN, A. D. ORTIZ, H. J. V. ZHENG, G. B. STANLEY
  • 65.02/M38: Information coding through adaptive control of synchronized thalamic bursting. *C. WHITMIRE, C. WAIBLINGER, C. SCHWARZ, G. STANLEY
  • 65.03/M39: Thalamic control of sensory perception in the awake behaving rat. *C. WAIBLINGER, C. J. WHITMIRE, C. SCHWARZ, G. B. STANLEY
Sunday, Oct 18, 2015, 8:00 AM -12:00 PM
  • 156.19/O31: Context-dependent information decoding of sensory-evoked responses in the rat vibrissa pathway. *H. J. ZHENG, C. WAIBLINGER, B. J. HE, G. STANLEY

Sunday, Oct 18, 2015, 1:00 PM – 5:00 PM

  • 268.22/CC2: Closing the loop around firing rate: Following dynamic trajectories. *A. WILLATS, M. F. BOLUS, C. J. WHITMIRE, C. J. ROZELL, G. B. STANLEY